HDL-コレステロールに対する尿酸,他の脂質及び肥満度との関係

抄録

We studied the relationships of HDL-cholesterol to uric acid, other lipids and degree of obesity, and the prevalence of primary hyper-HDL-cholesterolemia (over 100mg/dl) in 1342 men and 217women participating in an annual health examination.
Both male and female hypo-HDL-cholesterolemic subjects (under the mean value of controls by-2SD) had significantly higher average values of body mass index(BMI) and triglycerides. The mean serum urate levels were 6.5±0.2mg/dl(mean±SEM) in men (control,5.5±0.1mg/dl, p<0.01)and 4.8±0.3mg/dl in women (control,4.0±0.1mg/dl, p<0.05), respectively. In male hyper-HDL-cholesterolemic subjects (over the mean value of controls by+2SD), mean triglycerides levels appeared significantly lower (p<0.01), and that of female subjects had a tendency to be lower, with a mean values of 57±6mg/dl(control,73±4mg/dl). The mean serum urate levels were 3.6±0.1mg/dl in females, lower than the control values, and 5.8±0.1mg/cle in males, higher than the control levels, neither significantly. The higher serum urate level in males was attributed to the fact that 91.2% of the group were alcohol drinkers with an average daily alcohol intake of 30.4gr. Hyper-HDL-cholesterolemic subjects, whose HDL-cholesterol level was over 90mg/dl, showed a slightly lower mean values for BMI 20.7±0.7 in males(control,21.5±0.3) and significantly lower average levels for BMI 19.1±0.5 in females(control,20.9±0.3, p<0.05). However, hyper-HDL-cholesterolemic subjects as a whole did not show significantly lower values for BMI compared with controls.
Correlation coefficients between the serum HDL-cholesterol level and urate were significant -0.299 in males(p<0.05) and insignificant -0.102 in females. HDL-cholesterol is closely related to obesity, so hypo-HDL-cholesterolemic subjects have higher values of BMI, triglycerides and uric acid. The prevalence of primary hyper-HDL-cholesterolemia was 0.4% in males and 1.3% in females.