プリン・ピリミジン代謝
Online ISSN : 2187-0101
Print ISSN : 0916-2836
ISSN-L : 0916-2836
急性痛風性関節炎における一酸化窒素(nitric oxide;NO) の関与
松本 美富士坂野 章吾難波 大夫速水 芳仁上田 龍三
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1998 年 22 巻 1 号 p. 27-32

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Nitric oxide (NO) is a potent mediator of physiological functions and pathogenic reactions in human disease. Recently, considable evidence supporting the pathogenic mechanism of NO in some arthritides has been demonstrated. We investigated the role of NO in the pathogenesis of acute gouty arthritis. Synovial fluids (SF) from gouty arthritis contained a high level of NO, compared to SF from osteoar thritis, rheumatoid arthritis (RA) and palindr omic rheumatism patients. Monocytes from normal peripheral blood did not produce NO, synthetic monosodium urate (MSU) crystals. However, activated macrophage(Mφ)in SF from active RA patients produced a high level of NO after stimulation with fresh serum-treated MSU crystals. These NO productions were augmented by the addition of inflammatory cytokines (interleukin-1 β or tumor necrosis factor α). Presenceof a specific antagonist of NO synthetase (NGmonomethyl-L-arginine) effectively inhibited the production of NO from Mφ. From these findings NO would be a potent mediator of acute gouty arthritis. after stimulation with fresh serum-treated

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