Abstract
Flavonoids are plant secondary metabolites and have various biological activities. Additionally, more attractive bioactivities of the prenylated derivatives than those of original flavonoids have been frequently discovered. Therefore, development of the efficient and general prenylating procedure of flavonoids was desirable. We report here an efficient method for C-prenylation of flavonoids, and their evaluation of suppressive effect on disused muscular atrophy based on our recent report. Our procedure for prenylation of flavonoids is selective protection and/or deprotection of hydroxyl groups, palladium-catalyzed O-1,1-dimethyl-2-propenylation and the following regioselective Claisen rearrangement for the carbon-carbon bond formation as the key steps.
