癩の化学療法に関する研究(第16報)

鼠癩菌のストマイ耐性と化学療法剤併用投与によるINAH耐性の防止について

抄録

This paper reports the results of experiment if the murine bacillus can get resistance against S. M, and if the combined administration of INAH and S. M. can prevent the murine bacillus to obtain the resistance against INAH.
A. On the resistance of the murine bacillus against S. M. White rats inoculated with the murine bacillus subcutaneously were injected S. M. 5mg per day, six days in a week.
The leproma which had developed after the total 610mg S. M. and that had developed after the total 650mg S. M. and then received no treatment for 150 days were selected as the bacillus suspensions of respective dilutions for the next generation. These two strains were inoculated to white rats and S. M. of the same dose was injected in the same manner for 150 days.
The results show that the onset of the disease was inhibited to the same degree in both strains as S. M, sensitive strains reported by us (La Lepro, Vol. 23, No. 2, p. 23). The murine leprosy bacillus can not be strongly inhibited by S. M, in its multiplication, but can not get any resistance. (Fig. 1-3)
B. On the Prevention of INAI I Resistance by the Combined Administration of INAH and S. M.
The total 50mg INAH and 200mg S. M, were administered (INAH 4mg/ k and S. M. 20mg/k, daily, 6 days in a week) for 60 days to white rats with large leproma. Then the remaining leproma was extirpated and inoculated to white rats.
The lepromas in the 2nd generation were extirpated again and diluted and inoculated to white rats. The animals were administered with INAH from the next day for 150 days.
The result shows that an appreciable resistance could be observed compared with the sensitive strain reported by us (La Lepro, Vol. 23, No. 1, p. 22), but the onset was more clearly prevented than the resistant strain (La Lepro, Vol. 23, No. 1, p. 22). Therefore, INAH resistance can be prevented more strongly by the combination of INAH and S. M, than by the single usage of INAH. (Fig. 4 )