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Journal of Hematopoietic Cell Transplantation
Vol. 6 (2017) No. 2 p. 108-114

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http://doi.org/10.7889/hct.6.108

Original Article

 We studied the influence of second marrow donation from Japan Marrow Donor Program on donor’s physical loads and transplant outcomes. Eight hundred and twenty donors were available. The duration between first and second donation was about 4 years. The shorter term of coordination was confirmed in second donation compared to first donation. The duration of pain and recovery to daily life in second donation were shorter than those in first donation, although the degree of pain was same in first and second donation. Harvesting time and volume of bone marrow, total cell count, cell concentration, and cell count/patient weight in first and second donation were 74 min: 78 min (P<0.001), 821 mL: 848 mL (P=0.095), 160×108 cells: 139×108 cells (P<0.001), 2.0×107 cells/mL: 1.7×107 cells/mL (P<0.001), and 3.0×108 cells/kg: 2.7×108 cells/kg (P<0.001), respectively. Delayed hematopoietic recovery and poor overall survival were observed in patients who received bone marrow transplantation from second donation. The results indicated that long-term influence is unclear, but second donation is permissible for voluntary donors. Further analysis will be necessary to clarify the impact of second marrow donation on transplant outcomes.

Copyright © 2017 The Japan Society for Hematopoietic Stem Cell Transplantation

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