2018 Volume 7 Issue 3 Pages 82-89
The results of hematopoietic stem cell transplantation (SCT) after reduced-intensity conditioning (RIC) have not been compared with those after myeloablative conditioning (MAC) in patients under 55 years old. To clarify the efficacy and safety of RIC, we retrospectively analyzed the outcomes of 24 patients with RIC and 136 patients with MAC. In univariate analysis, RIC recipients had a higher incidence of disease progression (3y progression: MAC 31.9% vs RIC 42.1%, P=0.09) and shorter overall survival (3y OS: 46.5% vs 40.6%, P=0.12), but these differences were not significant. Progression-free survival and non-relapse mortality were not different between the two groups. Based on the multivariate analysis, RIC increased the incidence of disease progression (HR 2.12, P=0.01) and shortened OS (HR 1.75, P=0.04). In patients with a high disease risk, SCT after RIC increased the incidence of disease progression. In conclusion, as OS and PFS were similar between RIC and MAC, RIC may be considered as a treatment option.
