2020 Volume 9 Issue 1 Pages 1-5
Various kinds of late complication after hematopoietic cell transplantation (HCT) in children have been reported. These late complications are caused by preconditioning consisting of total body irradiation (TBI) and high-dose chemotherapy and/or chronic graft-versus-host disease (GVHD). The impact of late complications is serious, especially in infants/toddlers, even if the preconditioning does not involve TBI. We have to take into account that HCT in children has impacts on their growth, and such problems need to be addressed. This represents an important theme for follow-up and support of children going through education, employment, marriage and so on. In addition, we have to make efforts to develop strategies to reduce or avoid late complications.