弘前医学
Online ISSN : 2434-4656
Print ISSN : 0439-1721
原著
Involvement of endothelin-1 in adrenal catecholamine regulation
Manabu Murakami Takayuki NemotoHidetoshi NiwaTetsuya KushikataKyouichi OnoHiroyuki WatanabeKazuyoshi HirotaTakayoshi Ohba
著者情報
ジャーナル フリー

2014 年 65 巻 2-4 号 p. 218-226

詳細
抄録

Aims: The purpose of the current study was to evaluate the significance of the endothelin system in catecholamine release and synthesis in the adrenal gland.
Main Methods: Primary cultures of isolated bovine adrenal medullary cells were prepared. Gene expression, intracellular calcium changes, epinephrine release, and other factors were investigated.
Key findings: Expression of endothelin receptors in the rat adrenal gland was confirmed. Intravenous infusion of endothelin-1 (1.0 nmol) increased blood pressure (systolic and diastolic). Endothelin-1 stimulated intracellular calcium changes, resulting in increased nuclear factor of T cell (NFAT) activity and epinephrine release from cultured adrenal medullary cells. Furthermore, endothelin-1 increased catecholamine synthesis and caused hypertrophic changes in the cell size.
Significance: Our findings indicate involvement of the endothelin system in the sympathetic regulation of the adrenal medulla.

著者関連情報
© 2014 Hirosaki Medical Journal Editorial Board
前の記事 次の記事
feedback
Top