弘前医学
Online ISSN : 2434-4656
Print ISSN : 0439-1721
原著
What is happening in the ARDS piglet lungs: - the origin of B-lines on ultrasonography -
Masayuki Nishimura Toshihito TsuboKazuyoshi Hirota
著者情報
キーワード: B-lines, ARDS, TTE, TEE
ジャーナル フリー

2017 年 68 巻 1 号 p. 14-22

詳細
抄録

Background: B-lines are the important signs of pulmonary edema in acute respiratory distress syndrome (ARDS) detected with ultrasonography. We studied the mechanism of the origin and disappearance of B-lines in ARDS piglets using ultrasonography and microscopy.
Methods: ARDS was induced by intratracheal administration of 0.1M Hydrochloric Acid (HCl) in 23 anesthetized, ventilated piglets. The occurrence of B-lines was evaluated using transthoracic echography (TTE) and transesophageal echography (TEE). Changes in B-lines were recorded after a saline infusion into the pleural space, and after pulmonary consolidation developed and reached the pleura. Left lower lobe was excised and lung sections were examined by light microscopy.
Results: Following the saline infusion into the pleural space, we observed B-lines fanning out from the visceral pleura. As pulmonary consolidation developed, B-lines disappeared. The structure that B-lines fanned out from was the complex of thickened pleura and sub-pleural interlobular septa surrounded by gas. In the tissue where B-lines disappeared, the thickened sub-pleural interlobular septa were surrounded by cells and liquid.
Conclusions: We found that B-lines derive from the complex of thickened pleura and sub-pleural interlobular septa surrounded by gas. B-lines disappeared when the sub-pleural thickened interlobular septa were surrounded by cells and liquid.

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© 2017 Hirosaki Medical Journal Editorial Board
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