弘前医学
Online ISSN : 2434-4656
Print ISSN : 0439-1721
原著
Preliminary study on local medical treatment of aortic valve calcification: Drug delivery to aortic valve in rat
Zaiqiang Yu Xu LiuKazuyuki DaitokuKen-Ichi FurukawaIkuo FukudaShigeru MotomuraKazuhiko Seya
著者情報
ジャーナル フリー

2021 年 71 巻 2-4 号 p. 101-107

詳細
抄録

Background
Aortic valve stenosis (AVS) is the most common heart valve disease in elderly society. The effective treatment for AVS is surgical aortic valve replacement but with extremely invasive. Although transcatheter aortic valve replacement also is performed for highly risk patients with minimally invasive, it has to resolve the problem of bioprosthetic valve durability in future. However, there is no effective medical treatment established for AVS to inhibit acceleration of aortic valve calcification.
Objectives
We aimed to confirm whether the ascending aorta is the best location for AVS to innovate local and selective medical therapy or not.
Methods and Results
After anesthetized by isoflurane, the wild type rat was stablished on operating table. Opening chest to heart by median sternotomy approach, the catheter was inserted into left ventricular from apical for body perfusion. We injected saturated solution of amido black 10B (AB) into ascending aorta above sino-tubular junction about 0.5 cm from aortic valves without aortic dissection observed, and body perfusion was performed by saline containing heparin in order to prevent embolism happened in vascular. After 30 minutes, the heart with the ascending aorta was extracted. We used optical microscope to check the existence of AB at around of aortic valves or not. Interestingly, AB was detected at around of aortic valves and valsalva sinus of the aorta and myocardium in all rats.
Conclusions
These results suggested that AB injected is delivered from the ascending aorta to aortic valves through vasa vasorum. These data provide very important evidences for local medical therapy development for AVS patients.

著者関連情報
© 2021 Hirosaki Medical Journal Editorial Board
次の記事
feedback
Top