Preparation of an Ultrasound-Responsive Particle-Based on Supramolecular Chemistry

Abstract

The host-guest interaction of cyclodextrin (CD) involved in a polymeric network would be controlled by an ultrasound because the energy from the ultrasound can be transferred though the polymeric network. In this study, we examined preparation of a nano-particle with the network polymeric structure containing CD in response to the ultrasound. The nano-particle was prepared by crosslinking of a chitosan by using a tri-substituted caroboxymethyl β-CD. The mean diameter estimated by a DLS analysis was ca 122.5 nm, which is suitable for the DDS. A particle composed of β-CD-grafted chitosan and tripolyphosphate was prepared as a comparison sample to clarify the importance of the network structure. The release experiment with rhodamine 6G revealed that the nano-particle having the CD-containing polymeric network showed a sustained release by the exposure to the ultrasound, which was 4 folds delayed. Such behavior was not shown in the case of the comparison sample. Furthermore, the results of adsorption experiments under the ultrasound were consistent with the results of the release experiment. These results indicate the inclusion complexes in the CD-containing polymeric network were stabilized by the ultrasound.