2018 Volume 26 Pages 60-65
A synergistic study on computational fluid dynamics (CFD) simulation and sample preparation with highly branched cyclic dextrin (HBCD) as an excipient matrix for dry powder inhaler formulations were performed. The fine particles with HBCD were prepared by spray-drying. HBCD formulations had the highest drug content in terms of both isoniazid and rifampicin. Larger surface areas were obtained for SDPs of HBCD than those of other sugars. Regarding inhalational properties, HBCD formulations had higher emitted dose and fine-particle fractions than formulations of all other sugars tested. Our results confirm the feasibility of the formulation of hydrophilic and hydrophobic drug substances into a single-dosage preparation for pulmonary delivery using HBCD as an excipient. CFD analysis revealed that high inhalation performance was related to the true density and particle size of SDPs. The results on CFD simulations made a prediction about the particle behavior or deposition in pulmonary airways.