Hypertension Research
Online ISSN : 1348-4214
Print ISSN : 0916-9636
Clinical studies
Thrombospondin Expression in Aldosterone-Producing Adenomas
Haruhiko HATAKEYAMAMakoto NISHIZAWAAtsushi NAKAGAWAShigeru NAKANOToshikazu KIGOSHIIsamu MIYAMORIKenzo UCHIDA
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Volume 25 (2002) Issue 4 Pages 523-527

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Abstract

Thrombospondin (TSP) 1 and 2 are extracellular matrix proteins that appear to play a role in cell adhesion and cell migration. It has been demonstrated that the pattern of TSP expression is shifted from TSP1 to TSP2 under adrenocorticotrophic hormone treatment in bovine adrenocortical cells. We investigated the expression in human adrenal tissues by Northern blot analysis and correlated these data with the expression of the adrenocorticotrophic hormone-receptor (ACTH-R). All adrenal tissues (control adrenals, nonfunctional adenomas and ACTH-dependent aldosterone-producing adenomas (APA)) expressed both TSP1 and TSP2 mRNAs. Compared to control adrenals (TSP1 and TSP2 expression=100±12%, respectively), TSP1 expression was negatively (51±10%, p <0.01) and TSP2 expression was positively (289±36%, p <0.01) regulated in APA. No significant differences in TSP1 and TSP2 expressions were found between control adrenals and nonfunctional adenomas. In APA, TSP1 (r =-0.86, p <0.01) and TSP2 (r =0.88, p <0.01) expressions correlated closely with the expression of ACTH-R. These results suggest that ACTH activity plays an important role in regulating the expression of TSPs in human adrenal tissues. We speculate that the shift of expression observed in APA may be associated with the phenotype of the tumors. (Hypertens Res 2002; 25: 523-527)

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© 2002 by the Japanese Society of Hypertension
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