A Single-Nucleotide Polymorphism in C-Type Natriuretic Peptide Gene May Be Associated with Hypertension

抄録

We conducted an association study between genetic variants of C-type natriuretic peptide gene (CNP) and hypertension in a Japanese population. We found four genetic variants, two in the promoter region, one missense mutation, and one in the 3′-untranslated region (3′-UTR), and genotyped all four variants in 2, 006 subjects recruited from the Suita study. One of the variants, G2628A in 3′-UTR, was found to be associated with blood pressure. Multiple logistic analyses indicated that the genotype of the G2628A polymorphism (GG=1, GA+AA=2) (p =0.0034), sex (p =0.0288), alcohol consumption (p =0.0002), age (p <0.0001), and body mass index (p <0.0001) were predictors of hypertension. The odds ratio of the GA+AA genotype over the GG genotype for hypertension was 1.40 (p =0.0034, 95% confidence interval (CI) 1.12-1.75). Multiple logistic analyses in a younger subpopulation aged below 65 years indicated that the odds ratio of the GA+AA genotype over the GG genotype for hypertension was 1.58 (p =0.0024, 95%CI 1.18-2.12). Thus, the CNP G2628A polymorphism made an even greater contribution to hypertension in the younger subpopulation. (Hypertens Res 2002; 25: 727-730)