Hypertension Research
Online ISSN : 1348-4214
Print ISSN : 0916-9636
ISSN-L : 0916-9636
Clinical studies
A Consistent Abnormality in the Average Local Smoothness of Fetal Heart Rate in Growth-Restricted Fetuses Affected by Severe Pre-Eclampsia
Myung-Kul YUMKyungsik KIMJong-Hwa KIMEun-Young PARK
著者情報
ジャーナル フリー

2004 年 27 巻 12 号 p. 911-918

詳細
抄録

An abnormality in cardiovascular regulation during the prenatal period has been suggested to be the pathophysiological link between fetal growth restriction and adult hypertension. The purpose of this study was to determine how consistently abnormal the local smoothness of the very-short-term heart rate is in growth-restricted fetuses associated with severe pre-eclamptic pregnancy. Multifractal Hurst analysis on the structure function of heart rate was performed in control fetuses (n =150), in fetuses affected by severe pre-eclampsia and not showing growth restriction (n =66) and in fetuses affected by severe pre-eclampsia and showing growth restriction (n =58). The very-short-term (≤15 heart beats) generalized Hurst exponents of the order of -5 to 5 in three groups were compared. Each exponent quantifies an average local heart rate smoothness at 15-successive-heart rate sites, which were specified by the magnitude of the heart rate variation within the sites determined by and positively correlated with the order of the exponent. This means that the fetal heart rates within the sites of q ≥2 have a large fetal heart rate (FHR) variation, and those within the sites of q ≤-2 have a small FHR variation. In the fetuses affected by severe pre-eclampsia and not showing growth restriction, only values of the exponents of the order ≥2 were abnormally lower. In the fetuses affected by severe pre-eclampsia and showing growth restriction, the values of the exponents of all orders were abnormally lower. In conclusion, the local smoothness of heart rate is consistently abnormal regardless of the magnitude of heart rate variation within a very-short-term period in growth-restricted fetuses affected by severe pre-eclampsia. (Hypertens Res 2004; 27: 911-918)

著者関連情報
© 2004 by the Japanese Society of Hypertension
前の記事 次の記事
feedback
Top