Hypertension Research
Clinical studies
Sodium Intake and Cardiac Sympatho-Vagal Balance in Young Men with High Blood Pressure
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Volume 27 (2004) Issue 6 Pages 393-398

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We have previously reported that a high sodium intake increases sleep-time blood pressure (BP) in young men. However, there are cases in which this relation does not apply. To account for them, we investigated the relation between sodium intake and cardiac sympatho-vagal balance (SVB) in young men with high BP. Sodium intake was estimated from the amount of urinary sodium excretion over 1 week. Twenty-four-hour (24-h) urinary sodium excretion (Salt24), 24-h ambulatory BP and ECG were obtained on the last day of the observation period. As an index of sodium intake, the expression ln(Salt24/Cr24) (Cr24, 24-h urinary creatinine excretion) was used. From power-spectral analysis of ECG-RR intervals during sleep, we obtained the LF/HF ratio between the low-frequency component (LF) and the high frequency component (HF) and used it as an index of SVB. The subjects were male medical students divided into a normal BP group (N-group; n =103) and a high BP group (H-group; n =26, 24-h BP>125/75 mmHg). Mean ln(Salt24/Cr24) and LF/HF in the H-group were significantly higher than those in the N-group (LF/HF: 1.86±0.44 [SD] vs. 1.37±0.30, p <0.001). The calculated discriminant function (D) for the H-group and N-group was D =1.6x+5y-11, where x is ln(Salt24/Cr24) and y is LF/HF. This formula (D) resulted in high discriminant predictive accuracy (82%) between the groups. If D =0 (the value of the cut-off line determining separation of the groups), the relation y =-0.32x+2.2 (negative relation between y and x) was obtained. These results suggest that excessive sodium intake in combination with accentuated SVB (LF/HF) increases BP in young men. (Hypertens Res 2004; 27: 393-398)

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© 2004 by the Japanese Society of Hypertension
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