Does Dopamine Act on Myocardial Cells?

Yoshizumi Habuchi; Ling-Ling Lu; Toshiaki Komori; Shigetaka Okamoto; Masato Nishimura; Junichiro Morikawa; Manabu Yoshimura

doi:10.1291/hypres.18.SupplementI_S157

Yoshizumi Habuchi, Ling-Ling Lu, Toshiaki Komori, Shigetaka Okamoto, Masato Nishimura, Junichiro Morikawa, Manabu Yoshimura

Author information

Keywords: dopamine, myocardial cell, calcium current, transient outward current, action potential

JOURNAL FREE ACCESS

1995 Volume 18 Issue SupplementI Pages S157-S159

DOI https://doi.org/10.1291/hypres.18.SupplementI_S157

Details

Abstract

We examined the electrophysiological effects of dopamine on the single myocardial cells isolated from the rat and rabbit heart. Dopamine at a concentration of 1 or 10μM did not affect the L-type Ca²⁺ current (I_Ca) or the transient outward current (I_TO) in rat ventricular, rabbit atrial, ventricular, and sinoatrial node cells. It did not induce any detectable change in the action potential configuration of the rabbit ventricular cells either. We conclude that dopamine does not directly act on myocardial cells at least in terms of the electrophysiological properties. (Hypertens Res 1995; 18 Suppl. I: S157-S159)

Corresponding author

Register with J-STAGE for free!