電気学会論文誌C(電子・情報・システム部門誌)
Online ISSN : 1348-8155
Print ISSN : 0385-4221
<システム・計測・制御>
除算型フィードバックを有する生化学反応系の安定性解析手法
中茎 隆
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ジャーナル 認証あり

2016 年 136 巻 5 号 p. 617-624

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In this study, we propose an application methodology of the Nyquist criterion for biochemical reaction systems with the biological negative feedback loops. The molecular robot or a real biochemical reaction system such as an intracellular signal transduction system utilizes negative feedback regulation to enhance the stability and robustness. However, since such a system tends to be a high dimensional, nonlinear, and complex system with multiple feedback loops, it is troublesome to quantitatively evaluate the stability property of the whole system in terms of a particular feedback loop. We show that by modifying the system gain the Nyquist criterion can be appreciable for this problem, and as a result the stability margin can be calculated.

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