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電気学会論文誌C(電子・情報・システム部門誌)
Vol. 136 (2016) No. 5 P 617-624

記事言語:

http://doi.org/10.1541/ieejeiss.136.617

<システム・計測・制御>

In this study, we propose an application methodology of the Nyquist criterion for biochemical reaction systems with the biological negative feedback loops. The molecular robot or a real biochemical reaction system such as an intracellular signal transduction system utilizes negative feedback regulation to enhance the stability and robustness. However, since such a system tends to be a high dimensional, nonlinear, and complex system with multiple feedback loops, it is troublesome to quantitatively evaluate the stability property of the whole system in terms of a particular feedback loop. We show that by modifying the system gain the Nyquist criterion can be appreciable for this problem, and as a result the stability margin can be calculated.

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