DNA分解酵素検出を目的とした先端鋭利型対向電極に関する検討

奥 清明; 東谷 圭祐; 氷室 貴大; 江口 正徳

doi:10.1541/ieejeiss.141.860

Considerations on Triangular-Shaped Electrodes for Deoxyribonuclease (DNase) Detection

Seimei Oku, Keisuke Higashitani, Takahiro Himuro, Masanori Eguchi

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Keywords: Deoxyribonuclease (DNase), triangular-shaped electrodes, DNA immobilization, impedance measurement

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2021 Volume 141 Issue 8 Pages 860-865

DOI https://doi.org/10.1541/ieejeiss.141.860

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Abstract

In this paper, complex impedance locus of the triangular-shaped electrodes with immobilized λDNAs were calculated by numerical simulations. Compare with the impedance of the electrodes with immobilized λDNAs, its impedance after deoxyribonuclease (DNase) treatment were increased by about 3 times or more. The DNA molecules can be applied to electrical detection of DNase which is a candidate biomarker for acute myocardial infarction.

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