An Application of Genetic Algorithm for Parameter Estimation in Hodgkin-Huxley Equationunder Anesthetizing

Abstract

In this paper, an application of genetic algorithm for parameters estimation in Hodgkin-Huxley equation under anesthetizing. To achieve adequate estimation, five indexes which characterize action potential waveforms are introduced. The set of parameters are regarded as a chromosome of gene and are tuned by the genetic algorithm so that the calculated indexes are correspond to the measured indexes. By using the estimated parameters, the effect of consistency of anesthesia and elapsed time on the ion currents are discussed.