電気学会論文誌E(センサ・マイクロマシン部門誌)
Online ISSN : 1347-5525
Print ISSN : 1341-8939
ISSN-L : 1341-8939
特集論文
組織の形態形成解明に資するマイクロ流体デバイス内での血管網の構築とその応用
梨本 裕司寺岡 佑佳子有馬 勇一郎花田 三四郎中益 朗子小寺 秀俊西山 功一三浦 岳横川 隆司
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2018 年 138 巻 7 号 p. 275-280

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Luminal flow in a vascular network delivers nutrients and oxygen to cells in human bodies and applies mechanical stimuli to maintain vascular functions. Although many in vitro vascular models have been developed, there are no reports elucidating the effect of a long-term perfusion in a vascular network. Here, we report two types of microfluidic devices to investigate a vascular remodeling and long-term tissue culture in vitro. We observed formation of angiogenic spouts and a change of the volume of the vascularized tissue model in our microfluidic devices. Our method provides a new platform to study developmental biology with a long-term perfusion.

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