電気学会論文誌E(センサ・マイクロマシン部門誌)
Online ISSN : 1347-5525
Print ISSN : 1341-8939
ISSN-L : 1341-8939
特集論文
心臓拍動を模倣する流体キャパシタを集積した肝臓オルガノイド作製用マイクロ流体デバイス
呉 家旭平井 義和亀井 謙一郎土屋 智由田畑 修
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ジャーナル 認証あり

2019 年 139 巻 7 号 p. 209-216

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Liver organoids hold a great potential to understand liver development and contribute for drug screening and toxicological testing. However, conventional methods to generate organoids provide insufficient liver functions and less reproducibility, due to lack of controllability of cellular microenvironmental cues. To tackle these issues, we focus on one of the environmental cues, pressure stimuli by heart beating, and develop a microfluidic-based cell culture platform integrating a fluidic capacitor to produce pressure stimuli with hydrostatic pressure. Furthermore, we demonstrate a numerical simulation based on equivalent circuit model for designing the device parameters with sufficient accuracy. This device concept will provide insights into physical micro-environmental regulation on organoid development.

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