International Heart Journal
Online ISSN : 1349-3299
Print ISSN : 1349-2365
ISSN-L : 1349-2365
Clinical Studies
Periodontitis May Deteriorate Sinus of Valsalva Dilatation in Marfan Syndrome Patients
Jun-ichi SuzukiYasushi ImaiMieko AokiDaishi FujitaNorifumi TakedaNorio AoyamaKouji WakayamaYuichi IkedaHidetoshi KumagaiHiroshi AkazawaYuichi IzumiMitsuaki IsobeIssei KomuroYasunobu Hirata
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2016 Volume 57 Issue 4 Pages 456-460


Marfan syndrome (MFS) is a systemic connective tissue disorder that is caused by mutations of fibrillin-1. While MFS patients are at a high risk of periodontitis and aortic diseases, little causal information has been provided to date. To clarify the relationship, their oral condition and sinus of Valsalva (SoV) were evaluated.
The subjects were patients with MFS (n = 33) who attended the University of Tokyo Hospital. We divided them into two groups; MFS patients with highly dilated (the diameters were equal to or more than 39 mm) SoV (high group, n = 18) and MFS patients with mildly dilated (less than 39 mm) SoV (mild group, n = 15). Blood examinations, echocardiograms, and full-mouth clinical measurements, including number of teeth, probing pocket depth (PPD), bleeding on probing (BOP), and community periodontal index (CPI) were performed.
We found that the high group patients had greater rates of BOP compared to that of the mild group. Furthermore, the high group tended to have higher serum levels of C-reactive protein, matrix metalloproteinase-9, and transforming growth factor-β compared to the mild group.
Periodontitis may deteriorate SoV dilatation in MFS patients.

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© 2016 by the International Heart Journal Association
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