(1) A simple new recording apparatus for R.I. was deviced and its usefulness was discussed.
(2) Using this apparatus, hepatic blood flow was determined in 152 cases by Au198 colloid method.
(3) Simultaneous determinations of Au198 disappearance rate constant at periphery (Kp and KH) and accumulation rate constant in the liver (KL) were made in various diseases, such as liver cirrhosis and congestive heart failure etc.
(4) Similar examination is also made after rapid blood transfusion or administration of various drugs, including epinephrine, norepinephrine etc.
(5) The K value decreased in congestive heart failure and liver cirrhosis. An increase in the K value was observed in accordance with an increased cardiac output.
(6) An advantage of this method and its clinical significance were dis-cussed.