Japanese Heart Journal
Online ISSN : 1348-673X
Print ISSN : 0021-4868
ISSN-L : 0021-4868
A Clinical Study of the Effect of Coenzyme Q on Congestive Heart Failure
Taro ISHIYAMAYoshiharu MORITASeiichi TOYAMAToru YAMAGAMINozomu TSUKAMOTONoboru WADAMasaaki OHKUBOYuichi YAMAMURA
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1976 Volume 17 Issue 1 Pages 32-42

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Abstract

Expecting activation of myocardial energy liberation, coenzyme Q was applied as a treatment to 55 patients suffering from congestive heart failure. Daily doses of 50 to 100mg of coenzyme Q7 were injected intravenously in 21 cases for 3 to 35 days. Daily doses of 60mg of coenzyme Q7 were administered perorally in 17 cases for 14 to 196 days. Daily doses of 30mg of coenzyme Q10 were administered perorally in 17 cases for 7 to 182 days. Clinical effects were evaluated within 4 weeks by the criteria using a scoring method of severity of congestive heart failure which was devised by the authors. In summary a certain effect was found in 20 cases and a mild effect was observed in 29 cases. No significant changes were observed in heart rate and blood pressure. Exanthema appeared in 2 patients of the group of coenzyme Q7 intravenous injection. In conclusion the therapeutic effect of coenzyme Q was thought to be mild but stable in supplement to digitalis therapy in cases of congestive heart failure.

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© by International Heart Journal Association
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