Effects of Captopril and Prostaglandin I₂ on Vasocnstrictor Responses to Norepinephrine and Potassium Ions in Rat Mesenteric Artery

抄録

In the perfused rat mesenteric vascular bed, the effects of captopril and prostaglandin I₂, (PGI₂) on the vasoconstrictor responses to norepinephrine or potassium chloride were studied. Captopril or PGI₂ in the perfusate attenuated the vascular responses to norepinephrine in a dose-related manner, while these substances had no effect on the vascular contractions induced by potassium chloride. In preparations treated with indomethacin, the inhibitory effect of captopril on the vascular response to norepinephrine was similar to that found in the untreated preparations. These results suggest that, although the effect of captopril on the vascular reactivity is similar to that of PGI₂, the direct vascular action of captopril is not mediated by the synthesis of prostaglandins in the vascular bed