Relationship between Stroke-related Behavior and Plasma Norepinephrine Concentration in Stroke-prone Spontaneously Hypertensive Rats

Masaru Minami; Hiroko Togashi; Machiko Sano; Hideya Saito; Nishio Nakamura; Hisakazu Yasuda; Hideaki Kawaguchi; Kihito Takahashi; Hyoichiro Sakurai

doi:10.1536/ihj.25.833

Masaru Minami, Hiroko Togashi, Machiko Sano, Hideya Saito, Nishio Nakamura, Hisakazu Yasuda, Hideaki Kawaguchi, Kihito Takahashi, Hyoichiro Sakurai

著者情報

Masaru Minami
Department of Pharmacology, Hokkaido University, School of Medicine
Hiroko Togashi
Department of Pharmacology, Hokkaido University, School of Medicine
Machiko Sano
Department of Pharmacology, Hokkaido University, School of Medicine
Hideya Saito
Department of Pharmacology, Hokkaido University, School of Medicine
Nishio Nakamura
Department of Pathology, Hokkaido University, School of Medicine
Hisakazu Yasuda
Department of Cardiovascular Medicine, Hokkaido University, School of Medicine
Hideaki Kawaguchi
Department of Cardiovascular Medicine, Hokkaido University, School of Medicine
Kihito Takahashi
Department of Cardiovascular Medicine, Hokkaido University, School of Medicine
Hyoichiro Sakurai
Research Division, Mitsubishi-Yuka Laboratory of Medical Science Co., Ltd.

ジャーナルフリー

1984 年 25 巻 5 号 p. 833-835

DOI https://doi.org/10.1536/ihj.25.833

詳細

抄録

Previous study(1) has indicated that behavioral changes occur at the onset of cerebral accidents in stroke-prone spontaneously hypertensive rats (SHRSP). In the SHRSP stroke cases (SHRSP-stroke) in this study, the plasma norepinephrine concentration and blood pressure levels were higher than those in Wistar Kyoto rats (WKY) and stroke free SHRSP (SHRSP-control). These findings suggest that the increase in plasma norepinephrine level is at least in part associated with the blood pressure rise and behavioral changes in the SHRSP-stroke cases.

責任著者(Corresponding author)

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