International Journal of Microgravity Science and Application
Online ISSN : 2188-9783
PHOENIX-2
Crystal Structure Analysis of the 20S Proteasome Grown in Space: Comparison between Space and Ground Crystals
Yukio MORIMOTOMasayuki KAMONaoki FURUBAYASHIYuuki HIGASHINOKoji INAKA
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JOURNALS OPEN ACCESS

2020 Volume 37 Issue 4 Pages 370404-

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Abstract

Microgravity utilization in space is a powerful technique for high-quality protein crystallization. Drug design requires information regarding three-dimensional atomic coordinates from a precious protein structure at atomic resolution. Crystals obtained in space have greater availability for the analysis of drug/protein interactions compared to crystals on the ground. In this study, we assessed the reliabilities of crystal characterization based on the mosaicities of the space and ground crystals and determined a complex whole structure of the 20S proteasome with an anticancer drug.

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この記事はクリエイティブ・コモンズ [表示 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by/4.0/deed.ja
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