2017 Volume 16 Issue 1 Pages 8-15
Interleukin-34(IL-34)was recently discovered and shown to mediate inflammation and osteoclastogenesis. An in vitro study reported that the expression of IL-34 is stimulated by tumor necrosis factor-α via nuclear factor-kB activation in osteoblasts. The present study focused on the expression of IL-34 in resorbed root cementum using an experimental rat model of tooth movement.
Experimental tooth movement was induced by a quad helix-type device. The upper first molar was palatally moved by the appliance with a force of 10 or 50g for 21 days. We performed hematoxylin and eosin and immunohistochemistry staining for tartrateresistant acid phosphatase and IL-34 in the root resorption area.
In the heavy force(50g)group, few IL-34-positive odontoclasts were observed on day 7 in the root, but increased at days 14 and 21. Therefore, IL-34 may take part in the aggravation of root resorption.
