International Journal of Sport and Health Science
Online ISSN : 1880-4012
Print ISSN : 1348-1509
ISSN-L : 1348-1509
Aging and Health Promotion
The Effects of Walking Exercise Training on Immune Response in Elderly Subjects
Fuminori KimuraKazuhiro ShimizuTakao AkamaTakayuki AkimotoShinya KunoIchiro Kono
キーワード: walking, immunology, elderly
ジャーナル フリー

2006 年 4 巻 Special_Issue_2_2006 号 p. 508-514


The immune function declines in efficiency with advancing age, making the elderly less resistant to pathogenic microorganisms. The effects of walking exercise training (five 30-min walking sessions/week at 80% VT) on salivary secretory IgA (SIgA) and plasma lymphocyte subpopulations were studied in elderly subjects. Thirty sedentary, elderly subjects (8 men, 22 women; age 66.7±7.4 years) performed walking exercise for 3 months. Aerobic power, body composition, and immune function were examined before (Pre) and after training (3 months). Salivary SIgA flow rate were measured by enzyme linked immunosorbent assay (ELISA), while lymphocyte subpopulations were measured by flow cytometry. SIgA flow rate significantly increased at 3 months, especially in 64-year-olds and under (U-64), 65∼85-year-olds (65-85), and female elderly subjects. Number of total lymphocytes, NK cell, and memory-Th cell significantly decreased at 3 months. We conclude that 3 months of walking provides enhancement of mucosal immune function in elderly subjects, although it is not associated with an improvement in lymphocytes.

© 2006 Japan Society of Physical Education, Health and Sport Sciences
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