Case Reports
Seven Cases of Cultured Epidermal Autograft (JACE®) for Giant Congenital Melanocytic Nevus after Removal by Electric Dermatome and CO2 Laser
2020 年 1 巻 1 号 p. 33-37
詳細
2020 年 1 巻 1 号 p. 33-37
Giant congenital melanocytic nevus (GCMN) must be treated from the point of view of either cosmetics or the risk of malignancy. Since 2016, cultured epidermal autograft (JACE®) for GCMN has been covered by insurance in Japan, but there are few reports on its usefulness and postoperative course.
We performed excision of the nevus with electric dermatome and CO2 laser excision, followed by cultured epidermal autograft in seven cases and 11 sites of GCMN in the extremities and trunks. In all cases, 90% of the grafts engrafted and became epithelialized in about one week. All cases showed a reduction in the brown color of the nevus. Recurrence occurred in one site, and hypertrophic scar formation was found in the wound after transplantation in six cases. While cultured epidermal transplantation for GCMN can more safely reduce color tone with a small donor size compared to the conventional procedure, it remains necessary to determine how to reduce the risk of complications such as recurrent nevi and hypertrophic scar formation.
