RELATIVE DISTRIBUTION OF MANGANESE IN ORGANS OF RAT

Abstract

The relative site of manganese accumulation and the effects of dose and duration of manganese treatment on its distribution in different organs of rat have been in-vestigated. The pancreas was found to be the chief site of manganese accumulation followed by liver, kidney and brain. The concentration of manganese was found to be directly proportional to the dose injected for all the organs. With any dose the accumulation of this metal increased upto 30 days in pancreas and brain, while it did not change significantly after 20 days in liver and kidney.