FENITROTHION INDUCED ALTERATIONS IN CALCIUM AND MAGNESIUM AFTER DERMAL ABSORPTION IN RATS

Abstract

A single dermal application of Fenitrothion (750 mg/kg of body weight) was applied on rats and the effect was observed after 8 hr on organ size and organ levels of calcium and magnesium. Significant decreases in organ size of kidney and heart and increases in liver and spleen were observed. However, there was no change in the size of the brain. Calcium and magnesium registered a decrease in heart, kidney, liver and spleen but showed an increase in plasma suggesting migration of metals from the organs towards the circulatory system.