Effects of the Microsomal and Soluble Fractions from Livers of Rats Poisoned with CCl₄ on Mitochondrial Respiration

Abstract

The microsomal fraction (pellet: 105, 000 x g for 60 min) from the livers of rats poisoned with CCl₄ showed uncoupled normal mitochondrial oxidative phos-phorylation in vitro. The supernatant fraction (105, 000 × g for 60 min) antagonized the uncoupling action of the microsomal fraction and stimulated the respiratory control of mitochondria caused by central depression of state 4 respiration.