ORIGINAL ARTICLES Hepatic Mitochondrial and Microsomal Recovery of Rats Intoxicated with CCl<SUB>4</SUB>

Tohru HASEGAWA; Yukio HIRAI; Naomi KOGA; Katsumaro TOMOKUNI

doi:10.2486/indhealth.21.231

ORIGINAL ARTICLES

Hepatic Mitochondrial and Microsomal Recovery of Rats Intoxicated with CCl₄

Tohru HASEGAWA, Yukio HIRAI, Naomi KOGA, Katsumaro TOMOKUNI

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Keywords: Key words : Recovery-Mitchondria-Microsomes-Oxgen uptake-CCl₄

JOURNAL FREE ACCESS

1983 Volume 21 Issue 4 Pages 231-234

DOI https://doi.org/10.2486/indhealth.21.231

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Abstract

The hepatic mitochondrial and microsomal recovery of rats intoxicated with CCl₄ was investigated with specific reference to the oxygen utilization of liver slices. In control rats, the major oxygen utilization of the liver slices was at-tributed to mitochondrial particles. Since the mitochondrial oxygen utilization was inhibited by cyanide, the microsomal oxygen utilization was induced by NADPH and phenobarbital (a substrate for microsomal mixed function oxidase). Changes in oxygen utilization were observed in the recovery course of rats intoxicated with CCl₄, and the recovery of mitochondria was found to be faster than that of micro-somes. A sex difference was present in the recovery mechanism of the microsomes.

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