Kinetics and Dose Dependence of Glutathione, Glutathione-S-Transferase and Phosphoglucomutase in Liver and Kidney of Nickel Treated Partially Hepatectomized Rats

Abstract

Administration of nickel (50 μ moles Ni/kg as NiCl₂•6H₂O, subcutaneously) to partially hepatectomized rats at 8, 16, 24 and 72 hrs revealed that it did not produce any change in the levels of hepatic or renal glutathione at any time interval when compared with saline treated hepatectomized rats. Remarkable changes were however observed in glutathione-S-transferase and phosphoglucomutase at 16 and 24 hrs in liver while only at 8 hrs in kidney. The effect of various doses of nickel (50, 100 and 150 μ mole Ni/kg) at 16 hrs revealed that 100 μ moles nickel produced maximum enhancement in the levels of all these parameters in liver while in kidney practically no change was observed.