Exacerbation of Nickel Induced Oxidative Response by Vitamin E

Mirza M. HUSAIN; Nihal AHMAD; Sanjay GUPTA; Jai R. BEHARI; Syed K. HASAN; Sanjay K. SRIVASTAVA; Ramesh C. SRIVASTAVA

doi:10.2486/indhealth.33.143

Mirza M. HUSAIN, Nihal AHMAD, Sanjay GUPTA, Jai R. BEHARI, Syed K. HASAN, Sanjay K. SRIVASTAVA, Ramesh C. SRIVASTAVA

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Keywords: Vitamin E, Ni toxicity, Reactive oxygen species, Benzoate hydroxylation, Liposomal membrane damage

JOURNAL FREE ACCESS

1995 Volume 33 Issue 3 Pages 143-152

DOI https://doi.org/10.2486/indhealth.33.143

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Abstract

Vitamin E (α-tocopherol), a well known naturally occurring chain breaking antioxidant and a free radical scavenger was found to exacerbate nickel (Ni) toxicity in mice. Vitamin E (Vit. E) mediated enhancement of nickel toxicity was demonstrated by (i) enhanced mortality in mice treated with Ni and Vit. E (ii) increased hepatic lipid peroxidation, (iii) increased rate of benzoate hydroxylation, and (iv) liposomal membrane damage.

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