2015 年 35 巻 3 号 p. 137-139
A considerable number of reports show that administration of probiotics may prevent or alleviate allergy. These may be direct effects of bacterial components on immune system, or through indirect effects through alteration of intestinal microbiota. Animal and cellular studies imply that direct effects may be through inhibition of Th2 responses by enhancement of Th1 response, induction of apoptosis, induction of regulatory T cells, and other mechanisms. One mechanism of the indirect effects may be regulatory T cell induction by metabolites of microbiota. Further studies are required to fully understand the mechanisms.