抄録
Extracellular adenosine 5'-triphophate (ATP) mediates the immune response. Several ecto-enzymes hydrolyze ATP, including the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) and ecto-nucleotide pyrophosphate/phosphodiesterase (E-NPP) protein families. Among these, E-NTPD1, E-NTPD7, and E-NPP3 have been shown to regulate the immune response. E-NTPD1 is expressed in lymphocytes and myeloid cells and modulates their function. E-NTPD7, which is selectively expressed in the epithelial cells of the small intestine, regulates Th17 responses in the small intestine by controlling ATP levels. E-NPP3 is rapidly induced on activated basophils and mast cells, and regulates ATP-dependent activation in basophils and mast cells to prevent chronic allergic inflammation. Thus, ATP-hydrolyzing ecto-enzymes modulate the immune response through ATP hydrolysis.
