Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Gastrointestinal Diseases
Gastric Dysmotility Associated with Accumulation of Mitochondrial A3243G Mutation in the Stomach
Akihiro FUJIIMakoto YONEDAMasahiro OHTANIHiroto NAKAGAWATakanori KUMANOKoji HAYASHIAtsushi MURAMATSUSatoru TAKABATAKETohru IBIKo SAHASHITakeshi AZUMAMasaru KURIYAMA
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JOURNALS OPEN ACCESS

2004 Volume 43 Issue 12 Pages 1126-1130

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Abstract

  Objective  We analyzed the accumulation of a mitochondrial A-to-G mutation at nucleotide position 3243 (A3243G) in the stomach and gastric motility in patients with gastric symptoms, post-prandial nausea/vomiting and epigastralgia.
  Methods  Detection and quantification of A3243G mutation in mtDNA in the gastric mucosa, oral mucosa, leukocyte, and skeletal muscle were performed. Gastric motility was evaluated by gastric myoelectrical activity on electrogastrography (EGG), and gastric emptying was evaluated by measurement of plasma paracetamol concentration before and after meals.
  Patients or Materials  Four patients with A3243G mutation in the leukocyte mtDNA and gastric symptoms were examined.
  Results  The A3243G mutation was detected at higher percentages in the gastric body (69-94% for mutation; mean, 83%) than in the angle portion (37-82%; mean, 52%), the antrum (40-84%; mean, 57%) or leukocytes (28-52%; mean, 39%), and at slightly higher percentages than in the skeletal muscles (45-87%; mean, 70%) or oral mucosae (52-86%; mean, 69%) in the four patients examined. Abnormal EGGs were observed in the three patients examined. The pre-prandial myoelectrical activities were low in these patients (49% in patient 1, 54% in patient 2, 63% in patient 3; normal >70%). The plasma concentrations of paracetamol were low (3.6 μg/ml in patient 1, 2.4 μg/ml in patient 2, <2.0 μg/ml in patient 3; normal, 7-12 μg/ml).
  Conclusion  Accumulation of mitochondrial A3243G mutation in the stomach is a contributory factor in gastric dysmotility and gastric symptoms in patients with the mutation in their leukocytes.

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© 2004 by The Japanese Society of Internal Medicine
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