Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Gastrointestinal Diseases
Cerebral Sinus Thrombosis Associated with Severe Active Ulcerative Colitis
Shizuka MURATANaoto ISHIKAWAShoutaro OSHIKAWAJunichi YAMAGAMasaaki OOTSUKAHaruhiko DATEMichitaka KITANIHaruhiko INATSUTanenao ETO
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2004 Volume 43 Issue 5 Pages 400-403


A 19-year-old man with severe active ulcerative colitis was admitted to our hospital where he was prescribed 80 mg prednisolone and underwent leukocytapheresis (LCAP). Two weeks after initiating therapy, his symptoms had not recovered. We administered cyclosporin via continuous intravenous infusion for 12 days. Although his clinical symptoms improved, he complained of severe headache. Immediate plain computed tomography (CT) and magnetic resonance imaging angiography (MRA) revealed extensive thrombosis in the superior sagittal sinus and right transverse sinus. We treated this condition with the anticoagulant agent, heparin, which prevents and can treat venous thrombosis. We report an occurrence of cerebral sinus thrombosis accompanying ulcerative colitis, where active anticoagulant therapy was useful.

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© 2004 by The Japanese Society of Internal Medicine
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