Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Renal Diseases
Depressive State and Paresthesia Dramatically Improved by Intravenous MgSO4 in Gitelman’s Syndrome
Mayumi ENYAYoshinori KANOHTomoatsu MUNEMasayoshi ISHIZAWAHiroshi SARUIMayumi YAMAMOTONoriyuki TAKEDAKeigo YASUDAMinoru YASUJIMAShoji TSUTAYAJun TAKEDA
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JOURNALS OPEN ACCESS

2004 Volume 43 Issue 5 Pages 410-414

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Abstract

A 69-year-old woman was referred to our department for evaluation of hypokalemia, which had been treated by oral potassium for more than ten years. She complained of headache, knee joint pain, sleeplessness and paresthesia in extremities and, most prominently, depression. Laboratory data suggested Gitelman’s syndrome, which is caused by mutations in the gene encoding the thiazide-sensitive Na-Cl cotransporter. Direct sequencing of the gene in this patient revealed homozygous mutation R964Q in exon 25. Intravenous supplement of MgSO4 dramatically improved both the depression and the paresthesia, suggesting that hypomagnesemia played a role in the clinical manifestations.

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© 2004 by The Japanese Society of Internal Medicine
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