Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Gastrointestinal Diseases
Gianotti-Crosti Syndrome Caused by Acute Hepatitis B Virus Genotype D Infection
Kojiro MICHITAKANorio HORIIKEYan CHENTran Nhu DUONGIchiro KONISHIToshie MASHIBAYoshio TOKUMOTOYoichi HIASAYasuhito TANAKAMasashi MIZOKAMIMorikazu ONJI
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JOURNALS OPEN ACCESS

2004 Volume 43 Issue 8 Pages 696-699

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Abstract

A 12-year-old girl with Gianotti-Crosti syndrome caused by hepatitis B virus (HBV) infection was admitted due to eruption on her extremities. Laboratory findings revealed elevation of transaminase, positivity for HB surface antigen (HBsAg), and an IgM type anti-HB core. The eruption and level of transaminase improved, and HBsAg became negative within 2 months of onset. Analysis of the virus revealed it to be genotype D with a genomic length of 3, 182 bases and the HBsAg serotype was ayw3, which is very rare in Japan. The possible relationship between Gianotti-Crosti syndrome and HBV genotype D infection is discussed.

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© 2004 by The Japanese Society of Internal Medicine
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