Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Endocrine-Metabolic Diseases
Large Duodenal Somatostatinoma in the Third Portion Associated with Severe Glucose Intolerance
Ryosuke KIMURAYoshinari HAYASHIToyo TAKEUCHIManabu SHIMIZUMaki HIRATSUKAMichihiro YOSHIDAEiji HAMAJIMAMasaru IWATAMasami IMOTOHideo HATTORI
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JOURNALS OPEN ACCESS

2004 Volume 43 Issue 8 Pages 704-707

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Abstract

A 51-year-old man was admitted with hyperglycemia and a duodenal tumor. Although his glycemic control was poor, basal C-peptide levels were not suppressed. Further examination revealed a mass measuring 7.8 cm in diameter in the third portion of the duodenum. Duodenectomy revealed a slow-growing sessile tumor located near Treitz’s ligament. The immunohistochemical profile of sections of the specimen revealed the presence of somatostatin. The patient’s serum somatostatin was elevated to 300 pg/ml preoperatively, but was reduced to 10 pg/ml postoperatively. Glycemic control also normalized after the operation.

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© 2004 by The Japanese Society of Internal Medicine
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