Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Renal Diseases
Worsening Fluid Retention in a Patient with Hereditary Angioedema and End-stage Renal Disease
Isao OHSAWAAtsushi SATOMURAYoshinobu FUKEMutsuko HIDAKAMorito ENDOTakayuki FUJITAHiroyuki OHI
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2004 Volume 43 Issue 8 Pages 708-712


A 60-year-old woman who was diagnosed with hereditary angioedema (HAE) developed nephrotic syndrome, with end-stage renal disease (ESRD) occurring about 2.5 years later. During her slide toward ESRD, she experienced three severe episodes of angioedema that each resulted in significant fluid retention. Though the therapeutic administration of C1-inhibitor concentrate was effective in controlling her angioedema, seemed ineffective in preventing her from developing ESRD requiring hemodialysis treatment. We theorized that the patient’s low colloid osmolality and glomerular perfusion were important facilitators of her attacks of angioedema.

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© 2004 by The Japanese Society of Internal Medicine
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