Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Respiratory Diseases
Gefitinib as a First Line of Therapy in Non-Small Cell Lung Cancer with Brain Metastases
Atsuko ISHIDAKoji KANOHTakashi NISHISAKAYuka MIYAZUYasuo IWAMOTONobuoki KOHNOTeruomi MIYAZAWA
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JOURNALS OPEN ACCESS

2004 Volume 43 Issue 8 Pages 718-720

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Abstract

Two Japanese women were diagnosed as having well-differentiated adenocarcinoma of the lung with brain metastases. Since it was considered they could not tolerate conventional chemotherapy, we administered gefitinib without any previous systemic therapy. In both patients gefitinib acted dramatically on all the lesions including the brain metastases, resulting in a marked decrease of the elevated CEA levels, and improvement of their quality of life. Retrospective evaluation of epidermal growth factor receptor expression levels by immunohistochemistry revealed positive results in both cases. Though gefitinib has been recommended for patients previously treated with chemotherapy, it should be considered feasible as a first line therapy.

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© 2004 by The Japanese Society of Internal Medicine
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