Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Hematological Diseases
Sinus Histiocytosis with Massive Lymphadenopathy Associated with Malignant Lymphoma
Hirofumi SHODATeruaki OKAMorihiro INOUESeishi KUSAKAHideo TSUNEYOSHIJun MIYAZAKIShinji SUNAGA
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JOURNALS OPEN ACCESS

2004 Volume 43 Issue 8 Pages 741-745

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Abstract

Sinus histiocytosis with massive lymphadenopathy (SHML) is a distinct benign clinicopathological entity, characterized by painless enlargement of lymph nodes due to sinus histiocytosis. Here, we report a case of SHML with diffuse large B-cell lymphoma. A 64-year-old man was admitted to our hospital because of fever. He presented with enlargement of a small cervical lymph node and huge abdominal paraaortic lymphadenopathy. Cervical lymph node biopsy revealed SHML and bone marrow biopsy showed infiltration of large B-cell lymphoma. Several cases of SHML associated with lymphoma have been documented to date, but this type of simultaneous occurrence has not yet been reported.

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© 2004 by The Japanese Society of Internal Medicine
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