Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Rheumatic Diseases
Acute Respiratory Failure with Gross Hemoptysis in a Patient with Lymphangioleiomyomatosis as Part of Tuberous Sclerosis Complex
Kazumi YAMAMOTOFumio ANZAIKenji KUSAJIMANaoki YAMANISHIMasakazu YAMADA
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JOURNALS OPEN ACCESS

2004 Volume 43 Issue 8 Pages 755-758

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Abstract

A 29-year-old woman was admitted to our hospital with a 7-day history of elevated temperature to 39.5°C associated with headache and nausea. She had been diagnosed with tuberous sclerosis complex 10 years earlier. Her unconsciousness progressed, and she was diagnosed as having aseptic meningoencephalitis. The next day, she had a generalized seizure with severe hemoptysis, and she suddenly fell into severe respiratory failure (PaO2/FiO2=76.9). Transbronchial lung biopsy revealed the findings of lymphangioleiomyomatosis. It was suggested that neurogenic pulmonary edema accompanied with venous flow obstruction by lymphangioleiomyomatosis lesions resulted in diffuse pulmonary hemorrhage with resultant gross hemoptysis accelerating to severe hypoxemia.

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© 2004 by The Japanese Society of Internal Medicine
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