Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
ORIGINAL ARTICLES
N-isopropyl-p- 123I Iodoamphetamine Single Photon Emission Computed Tomography Study of Parkinson’s Disease with Dementia
Hideaki MATSUIFukashi UDAKATakafumi MIYOSHINarihiro HARAAkiko TAMURAMasaya ODATamotsu KUBORIKazuto NISHINAKAMasakuni KAMEYAMA
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JOURNALS OPEN ACCESS

2005 Volume 44 Issue 10 Pages 1046-1050

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Abstract

Background Intellectual deterioration occurs in 10-40% of patients with Parkinson’s disease. However, there are many conflicting studies on its relation with brain perfusion and the nature of this dementing process remains controversial.
Objective To compare cortical perfusion by SPECT using 123I-IMP between Parkinson’s disease patients with dementia and those without dementia and to investigate the correlation between dementia in Parkinson’s disease and brain perfusion in various areas.
Methods Fifty-two cases of Parkinson’s disease and 10 control cases were studied. The Parkinson’s disease with dementia group included 30 cases and the Parkinson’s disease without dementia group included 22 cases.
,Results By multiple logistic regression method, we demonstrated significant hypoperfusion in the occipital cortex in Parkinson’s disease with dementia.
Conclusions The cause of dementia in Parkinson’s disease may vary. We demonstrated that occipital hypoperfusion was closely correlated to dementia in Parkinson’s disease compared to frontal, parietal and temporal perfusion.

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© 2005 by The Japanese Society of Internal Medicine
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