Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Anaphylaxis to Aprotinin in Fibrin Sealant
Toshihiro SHIRAIHiroshi SHIMOTAKingo CHIDAShinichi SANOYasuo TAKEUCHIHiroshi YASUEDA
Author information
JOURNALS OPEN ACCESS

2005 Volume 44 Issue 10 Pages 1088-1089

Details
Abstract

A 50-year-old man with chronic otitis media was admitted to our hospital for investigation of lung cancer. He had received repeated instillations of fibrin sealant (Bolheal) in myringoplasty 7 times over 12 months. During the lower lobectomy, soon after fibrin sealant was applied to seal bronchopleural fistulas, systolic blood pressure decreased to 60 mmHg. Treatment with epinephrine and dopamine was required until his condition improved 2 days later. The specific IgE antibody was detected for the solution for fibrinogen and factor XIII containing bovine aprotinin. Cross-reactivity between purified aprotinin and the solution was noted by competitive ELISA inhibition tests.

Information related to the author
© 2005 by The Japanese Society of Internal Medicine
Previous article Next article
feedback
Top